Read the post here.

Over at Wired Playbook, I have a new article highlighting a sports performance-enhancing technique where blood flow is temporarily reduced to a limb, in order to prime the muscle for future stress during exercise:

The study builds off research first conducted in the 1980s by cardiovascular pioneer Keith Reimer that examined infarcts, areas of dead cardiac tissue that resulted after heart attacks, when blood flow (and, hence, oxygen) were cut off for extended periods of time. Reimer and his colleagues discovered that much less heart muscle deteriorated when the tissue had previously experienced a few training sessions where blood flow was slightly reduced.

It was as if practice makes perfect, and the previous bouts of low blood flow, which researchers refer to as ischemic preconditioning, primed the heart muscle to endure more serious, even catastrophic, events. When a life-threatening heart attack transpired, instead of shriveling away, the preconditioned heart muscle seemed to stand strong.

Read the full story here.

Photo via Flickr / jasleen_kaur

Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, & Redington AN (2010). Remote Preconditioning Improves Maximal Performance in Highly-Trained Athletes. Medicine and science in sports and exercise PMID: 21131871

Rhabdomyolysis is caused by severe injury to muscle cells.  The condition is serious, and can lead to kidney failure if not properly treated.  Basically, muscle cells break down and release byproducts in the bloodstream.  One particular protein, myoglobin, is especially hard on the kidneys.  Rhabdomyolysis usually occurs when your average couch-potato decides to head to the gym for the first time in months, pushes his-or herself to the brink of exhaustion, and doesn’t drink enough water.

So today’s NYT story that said twenty-four athletes from McMinnville High School in Oregon were diagnosed at their local hospital with rhabdomyolysis caught my attention.  The players began complaining about symptoms — which typically include sore/swollen muscles and dark urine –  a few days after an intense preseason workout.

Was the summer layoff to blame?  Did the players report to camp out of shape, force their way through an intense workout, and not stay properly hydrated?  Maybe.  But doctors aren’t ruling out the possibility that supplements may have been involved.  Some of the student-athletes reported they regularly consumed  a protein shake, but weren’t sure exactly what was in it.

Creatine is a popular supplement among high school and college power athletes.  The supplement works by  increasing water retention in the body, which makes the muscle fibers larger.  But if the water pressure inside the cells is high enough, it’s possible the increased stress could potentially break down the cells themselves.  In fact, there have been a few case studies showing that taking creatine supplements, especially in high doses, may trigger rhabdomyolysis.

Granted, there are a number of compounding factors at play.  And we don’t even know if creatine was in the protein shake or not.  But it certainly makes you wonder when you see a wave of rhabdomyolysis occur in otherwise healthy young athletes.

So I’ll keep my eyes peeled for the results of the lab reports, which should surface in the coming days.

photo via Flickr @rdesai

Exercising people are happy people.

Nonsense. Ever see someone’s face at mile 20 of a marathon? Do they look happy to you?

OK, maybe people aren’t happy while exercising, but evidence shows they’re better off, in general, after the fact. Physical activity has a positive effect on mood, and is considered a valid treatment strategy to battle anxiety disorders and even depression. Although most explanations are somewhat wishy-washy, researchers believe that hedonistic value of exercise is important in mental health. Exercise simply makes us feel good about ourselves. And this is not only true in humans, but in animals, as well. Rats and mice that are given free access to a running wheel will use it, and lab rodents typically won’t do anything that doesn’t provide them some sort of pleasure.

Read more…

It’s 6am and my alarm clock is buzzing, but I don’t hear it. I don’t even move. But the incessant noise wakes my wife, and her gentle nudges (read: elbows) and soft whispers (read: expletives) eventually convince me to get out of bed. Read more…

My inbox flooded with links to the report released by NIH (and evangelized by TIME) stating that lifestyle interventions (diet, physical activity, mental exercises, etc.) may not be that effective in preventing Alzheimer’s Disease.

Before I mount my full counterattack, I need to carefully read through the studies the meta-analysis cites.  Still, a quick glance at the exclusion criteria of the meta-analysis reveals the authors limited their review to studies using patients over the age of fifty.  So really, these results imply that lifestyle modifications may not prevent, delay, or treat Alzheimer’s Disease if you start these changes later in life.

My second point is that all lifestyle modifications are not created equal.  Scientific evidence in animal studies suggests that of all interventions, aerobic exercise is our best chance of staving off cognitive decline.  In fact, this meta-analysis also found some correlation between exercise and preserving or improving cognitive ability.

There’s a good article in The Economist that discusses the failures of the drug industry to find a solution to treating Alzheimer’s Disease.  One particular quote resonates with my feelings on the NIH report:

Another fundamental problem is that, whatever is causing the damage, treatment is starting too late. By the time someone presents behavioural symptoms, such as forgetfulness, his brain is already in a significant state of disrepair. Even a “cure” is unlikely to restore lost function.

We’ve all heard the mantra: keep LDL levels – the “bad” cholesterol – down, and the “good” HDL cholesterol up. But thanks in part to the ubiquity of statins, such as Lipitor, which allow us to simply pop a pill to limit LDL production in the body, we’ve recently adopted tunnel vision when thinking about managing cholesterol. LDL levels are all we seem to care about now, as we strive for lower and lower numbers at each visit to the doctor’s office.

However, I think we’re missing the bigger picture by focusing solely on LDL. First, it’s made us reliant on medication to solve a problem that can many times be addressed with changes in diet and exercise regimes. Once someone starts Lipitor treatment, they’ll be taking it for life, and if LDL levels don’t quite get as low as they should, it’s all too easy to solve the problem by increasing the dose. When patients first begin Lipitor treatment, physicians typically prescribe the lowest possible amount, 10mg. However, dosing can go as high as 80mg, which begs the question: Do higher doses of the drug really improve outcomes?

Read more…

A few months ago, a story ran in Wired Magazine that described a noticeable shift in the scientific method, and attributed the change to our ability to produce and store large amounts of data.
Historically, the scientific method was built around a testable theory.  But in the 21st century, theories were becoming obsolete; the data simply spoke for itself.

Data from our bodies is no exception — physiologic data can now be accessed as a real-time data stream thanks to personal health monitors. But does the vast amount of data we get from our bodies make us any healthier? Do we need to collect data 24-hours a day in order to learn something interesting about our health? Is it even feasible to wear these sensors all day, every day?

I am embarking on a new self-tracking experiment to answer these questions (and possibly a few others). For 30 days, I will be using devices such as the Zeo personal sleep coach, the Philips DirectLife activity monitor, the Mio Motiva wristband on-demand heart rate monitor, and the Nike+ sportband. The goal of this study is not to pit one device against another; rather, I want to focus on what the data tells me, and how I can best use it to stay healthy.

I’ll get a blog post up here at least once a week, all the while working on a longer story about the journey that will be released at the end of the month.

Stay tuned. It should be a fun ride…

from: well.blogs.nytimes.com

The afternoon of Day 1 of the Health 2.0 Conference was highlighted by the session, “The Patient is In”.  First up, a video that documented the experiences of a group of people that recently started using patient health tools, such as online health journals that track diet or exercise, support sites for quitting smoking, or home blood test kits.

Read more…